Protein name:
Mucin-4 (MUC-4) ;
Alternative:
Pancreatic adenocarcinoma mucin ;Ascites sialoglycoprotein (ASGP) ;Testis mucin ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.
Function:
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 "Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
Subcellular Location:
Membrane
Single-pass membrane protein
Secreted
Secreted by proteolytic processing.
Protein Attributes:
50:
MRGPHWRVPW | LCLSCLYSCL | LLLPDALATT | STQTPMSLSS | STRTSQMSSQ |
100:
ASTSSTSSDR | RTSKTEQTST | RDTPSSITTV | SQSHHTTSME | TSKPQTTTTT |
150:
EVTTSTPSAS | SRDQIQTETS | SQRTISPDGT | TTSHAPSISS | SAPSTTHMLT |
200:
TTSSTESTSV | DSGHTTAITT | QGLTPATAQV | SLTPSSQNMS | TVSTPITSTL |
250:
TQRQHTGSKQ | TSSKSQVNIV | TSTLSTSTSD | STPAQTMSQV | TSSSDKRTKP |
300:
STSGVSSTSL | TTTEVLTQTS | STDSAPGNTT | LRITQNSTTH | TTKVSTTSTP |
350:
QKLSPVSTLI | NSSQKMSTLP | QNQHTESMDT | SRQPQTTTTT | EVTTSTPSAS |
400:
SLHQIQTETN | SQKTISPGET | TTSHAPNMRS | SPPKTSQILT | TMPSTKSTSV |
450:
DTKQTKAITT | KVSTPDTTQV | SMTPSSQKLP | THSTSTQELT | SSYSQHIQSK |
500:
GTSSKSQTTT | NTKVNTSTPS | ASSRDKIQTE | TSSQRTNSPG | EKRTSHGPSM |
550:
SSSAPSTTHM | LSTTSSNQST | SVDTGQTTSV | TAQGSTPAIT | QTSLTPSSQN |
600:
MSTVSTPITS | TQILSTLPQS | QHTGSMGTSS | NPQTTTSPVV | TTSTPSGTSG |
650:
DQIQTETSSQ | RTISPGKTTI | SHAPNINSSA | PSTTHMLSTT | SSTQSTSGDT |
700:
RHITAGRTQG | STPATTQTSL | TPSSPXXXXX | XXXXXETETS | SQRTISPGET |
750:
TTSHAPIMSS | SPPSSTHMLS | TASSTEITSV | DTRHTTAIMT | QGSTPATTQV |
800:
SPSSQNMSTV | SAPITSTHIL | STLSQSQHTG | SKGTSSNPQT | TTTPVVTTST |
850:
PSASSRDQIQ | TETSSQRTIS | PGKTTTSHVP | NMNSSAPSTT | HILSTTSSIQ |
900:
STSGDTRHTT | AVRTQGSTPA | TTQVSLTPSS | QXXXXXXXXX | XETETSSLRT |
950:
ISPDGTTTSH | ASSMSSSSPN | TTHLLFTTSS | TESTSVDTGH | STVITTHGST |
1000:
LATTQVSLTP | SSQNMSTVSA | PITSSQILST | LRQSQHTGSK | GTSSNHQTTT |
1050:
TPVVTTSTPS | AASRDQIQTE | TSSLRTISPD | GTTTSHASSM | SSSSPNTTHL |
1100:
LITTSSTEST | SVDTGHSTVI | TTHGSTLATT | XXXXXXXXXX | ETETSSQRTI |
1150:
SPGKTTTSHV | PNMNSSAPST | THISSTTSSI | QSTSGDTRHT | TAVRTQGSTP |
1200:
ATTQVSLTPS | SQXXXXXXXX | XXETETSSQR | TISLGETTTS | HAPIMSSSPP |
1250:
SSTHMLSTAS | STEITSVDTG | HTTAIMTQGS | TPATIQVSPS | SQNMSTVSAP |
1300:
ITSTHILSTL | PKSQHTGSKG | TSSNPQTTTT | PVVTTSTPSA | SSRDQIQTET |
1350:
SSQRTISPGK | TTTSHVPNMN | SSAPSTTHIL | STTSSTQSTS | GDTRHTTAVR |
1400:
TQGPTPATTQ | VSLAPSSQNM | STLSAPITSP | QNFSTLPQNQ | HTGSMGTSSN |
1450:
PQSTTIPEVT | TSTLSASSRD | QVQTETSSQR | TIPPGETTTS | HASSLSSSGP |
1500:
STTNMLTRTS | STQITSGDTR | HTTAIVTQGS | TPATTQTSLT | PSSQNMSTVS |
1550:
APITSSQILS | TLRQSQHTGS | KGTSSNHQTT | TTPVVTTSTP | SATSRDQIQT |
1600:
ETSSLRTISP | GETTTSHASS | LSSSGPSTTN | MLTRTSSTQI | TSGDTRHTTA |
1650:
IVTQGSTPAT | TQTSLTPSSR | NMSTVSTPIT | STHKLSTLPQ | RQHTGSKGTS |
1700:
SNPQTTTTPE | MTTSTPSATS | HDLIETETSS | QRTISPGETT | TSYAPIMSSS |
1750:
APSTTHMLST | TSSTRSTSVD | TRHTTTLMTQ | GSTPATTQVS | PSSKNMSTVS |
1800:
TPITSTHKLS | TLPQSQHTGS | KGTSSNPQTT | TTPEVTTSTP | SATTRDQIQT |
1850:
ESSSQRTISP | GETTTSHAPS | MSSLAPSTTH | MLSTTSSSQS | TSGDTGHTTA |
1900:
VRTQGSTPAT | TQVSLSSQNI | STVSTPMTST | HKLSTLPQSQ | HTGSMGTSSN |
1950:
PQTTTTPEVT | TSTPSATSYD | QIQTETSFQR | TISPGETTTS | HAPSMSNSAP |
2000:
SSTHKLSTAS | STEITSVDTR | HTIAITTEGS | TLANTQTSLT | PSSQNMSTVS |
2050:
APITSSQILS | TLRQSQHTGS | KGTSSNHQTT | TTPVVTTSTP | SATSRDQIQT |
2100:
ETSSLRTISP | DGTTTSHASS | MSSSSPNTTH | LLITTSSTES | TSVDTGHSTV |
2150:
ITTHGSTLAT | TQVSLTPSSQ | NMSTVSMPST | SSQELTSLPQ | RQHTGSMETS |
2200:
SQPQNITPTV | VTTSTLLSFS | RGSTELQTMS | WGTSSSGTIT | TLSTPVRNTS |
2250:
PASTSGILTS | TLTTSGNTGY | TGVTRSLGVI | TSRVTSTSLP | GKSTVVHSTP |
2300:
AQPLSAHSQS | HQTYGTGTPS | TSQISILPDV | TSEKHVASSP | GPTVTESFSH |
2350:
VSSSSGLTTK | TDNDRNTAVS | ATSSTLTSPS | PTTASRSTVP | LPSLLPDQGI |
2400:
SLFPYGSEVG | DQNLFARTVD | FNSPIFKILI | GFPLGSSLRD | SFYVTDNGQI |
2450:
IFPESDYDVF | SYPNPPQRGF | TGRERVAMVA | PFWADADFSS | SRGAIFYQEY |
2500:
VTFYNGHHQL | IREVETLIND | FTSSWGYRAK | WTLKVTWVNV | PAYTAQESFG |
2550:
TNTYQAILST | DGSRSYALFL | YQNSGMRWDV | TQEPYNRVLM | GFSSGDGYFE |
2600:
NSPLTFRPAM | EKYRPDRFLN | SKLGIRGLQV | YRLHGEERPN | YRLKCLRWLE |
2650:
SQPQQPSWGW | SSVSCPCSWQ | QGQRDFRFRP | INPGWWDRQL | CSFSSGRGGV |
2700:
CCSYGAWGEF | REGWRMHSPW | QFDEEQEAQN | WCCQWNDKPS | FCVWYQLRRP |
2750:
RVSCAGYRPP | RPAWTFGDPH | ITTLDNANFT | FNGLGDFLLV | QAQDRNSSFL |
2800:
LEGRTAQTGT | AKATNFIAFA | AQYNTSSLKS | PITVQWFLEP | SDKIRVVYNN |
2850:
QTVAFNTRDT | EVLPIFNTTG | VLLTQNGSQV | SANFDGTVTI | SVIARSNILH |
2900:
ASSSLSEEYR | NHTEGLLGVW | NDNPEDDFRM | PNGSTIPSNS | SEETLFFYGM |
2950:
TWHVNGTGLL | GIRADPLPTK | FTPIFLSQLL | NQSASGEDLA | SGCKGDRKCM |
3000:
FDILATGNRT | IGQSTNSILN | EFQHMNDTLN | QYPPSINCSS | KIQAYKGQTV |
3050:
TTEITSNSKD | ATLSLSKKCS | GFQLFENGSL | QWTPTSPEAC | TLEILARDVR |
3100:
TNLSWVLQPK | TVACFCSKEE | QCLYNETSKE | GNSSLEVTSC | KCDGDTFGRL |
3150:
CERFKDPCDE | PCFPNVNCIP | GKGCEACPPN | TTGDGRHCAA | LEDSCPNRSC |
3200:
PVNYCYNNGH | CGISEAPGCQ | PTCTCPPAFA | DNRCFLAGNS | FTPTISTELP |
3250:
LRTIMLSLRE | DENASAADVN | ASVANILENL | DMRAFFSNSL | VELIRTSPGA |
3300:
QPSSKSIHHW | KVTSHFKYRP | RGPLIHYLNN | QLIGAVMEAF | LLQARQERQK |
3350:
RSGEARKDVH | FFPISRADVQ | DQMALNLSML | EEYFTCDGYK | GYHLVYSPQD |
3400:
GVTCVSPCSE | GYCHNGGQCK | HLPDGPQCSC | ASFTIYTSSG | KHCEHLSVKL |
3443:
GAFYGILFGT | LGALLLLGIL | AFMIFHFCGC | SMNKFSYPLD | SEL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Mouse MUC-4
ELISA Kit for Mouse MUC-4
ELISA Kit for Mouse MUC-4
Polyclonal Antibody for Mouse MUC-4
Polyclonal Antibody for Mouse MUC-4
Polyclonal Antibody for Mouse MUC-4
Monoclonal Antibody for Mouse MUC-4
Monoclonal Antibody for Mouse MUC-4
Monoclonal Antibody for Mouse MUC-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
strain :
129/SvJ .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-231
strain :
CD-1 .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3076-3443
strain :
FVB/N .
tissue :
Colon .
4.
"Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways."
Lee C.G.
,
Homer R.J.
,
Cohn L.
,
Link H.
,
Jung S.
,
Craft J.E.
,
Graham B.S.
,
Johnson T.R.
,
Elias J.A.
J. Biol. Chem.277:35466-35474(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 3181-3351
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 3343-3443
strain :
CF-1 .
tissue :
Uterine horn luminal epithelium .